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Glycogen Metabolism

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Glycogenesis (synthesis of glycogen) &
Glycogenolysis (breakdown of glycogen)

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Gluconeogenesis

  • formation of glucose from proteins and fats (non carb sources)

  • glycerol backbone from TGs, lactic acid, and certain amino acids can be converted by the liver into glucose

  • stimulated by cortisol and glucagon

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Glycogenesis

Glucose -> Glycogen

  • occurs in liver, muscle and adipose tissue

  • primer needed: pre existing glycogen or glycogenin

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Branching

  • more soluble and compact

  • more non-reducing ends

  • glucose is added to the non-reducing end

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Glycogenolysis

Glycogen -> G1P -> G6P -> glucose

  • important site for hormonal and allosteric regulation

Debranching

  • cuts from non-reducing end

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Regulatory role of Insulin
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Overview

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©2023 by Syracuse University Dr.Margaret Voss

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